SNAP23 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for SNAP23 抗体 (Internal Region) (ABIN499144)
抗原
See all SNAP23 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
序列
- C-QIKRITDKAD
-
特异性
- This antibody is expected to recognize both reported isoforms (NP_003816.2 and NP_570710.1).
-
交叉反应 (详细)
-
Species reactivity (expected):Mouse, Rat, Bovine.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
-
免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_003816.2 and NP_570710.1. Genename: SNAP23
-
-
-
-
应用备注
-
Peptide ELISA: Limit Dilution: 1/8000. Western blot: 0.1-0.3 μg/mL. This antibody detects a band of approx. 26 kDa Human Placentalysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))
-
别名
- SNAP23
-
背景
- Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.Synonyms: SNAP-23, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23
-
分子量
- 23.4kDa (NP_003816.2
-
基因ID
- 8773
-
NCBI登录号
- NP_003816
-
UniProt
- O00161
抗原
-