Phospholamban 抗体 (N-Term)
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Quick Overview for Phospholamban 抗体 (N-Term) (ABIN499141)
抗原
See all Phospholamban (PLN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- KVQYLTRSAI RR-C
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特异性
- Recognizes Phospholamban / PLN.
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交叉反应 （详细）
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Species reactivity (expected):Pig, Bovine.
Species reactivity (tested):Human, Rat. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- Peptide with sequence from the N Terminus of the protein sequence according to NP_002658.1. Genename: PLN
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anti-Phospholamban (PLN) (AA 1-52) antibody
PLN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-30) antibodyPLN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (pSer16) antibodyPLN 适用: 人 ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (N-Term) antibodyVerified PLN 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-22), (N-Term) antibodyPLN 适用: 人 WB 宿主: 兔 Polyclonal RB44799 unconjugated
anti-Phospholamban (PLN) (pThr17) antibodyPLN 适用: 人, 大鼠 WB, DB 宿主: 兔 Polyclonal RB24137 unconjugated
anti-Phospholamban (PLN) (AA 1-35), (N-Term) antibodyPLN 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (Thr17) antibodyPLN 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-35) antibodyPLN 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-30) antibodyPLN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Peptide ELISA: Limit Dilution: 1/8000. Western blot: 0.01-0.03 μg/mL. This antibody detects a band of approx. 13 kDa band in Human andRat Heart lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Phospholamban (PLN)
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别名
- Phospholamban
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背景
- Phospholamban (PLB/PLN) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains cAMP-dependent protein kinase phosphorylation sites and is highly basic and readily cleaved by proteases, whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer. PLB is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.Synonyms: Cardiac phospholamban, PLB, PLN
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基因ID
- 5350
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NCBI登录号
- NP_002658
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UniProt
- P26678
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途径
- Negative Regulation of Transporter Activity
抗原
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