Superoxide dismutase copper chaperone 抗体
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北京 101111
Quick Overview for Superoxide dismutase copper chaperone 抗体 (ABIN499056)
抗原
See all Superoxide dismutase copper chaperone (CCS) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of CCCS protein. (region surrounding Pro271)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 175-274) antibody
CCS 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E2 unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 23-269) antibodyCCS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 1-274) antibodyCCS 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (C-Term) antibodyCCS 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 175-275) antibodyCCS 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E2 unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) antibodyCCS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 27-268) antibodyCCS 适用: 大鼠 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 27-268) antibodyCCS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (AA 1-274) antibodyCCS 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Copper Chaperone For Superoxide Dismutase (CCS) (C-Term) antibodyCCS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))
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别名
- CCS
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背景
- Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Copper chaperone for SOD-1 (CCS) is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. CCS interacts with both wildtype and mutated forms of SOD-1 through CCS domains that are homologous in SOD-1. CCS exists as a homodimer that may form a heterodimer with SOD-1 during copper loading. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. The gene for CCS maps to human chromosome 11q13.Synonyms: SOD-4, Superoxide Dismutase Copper Chaperone
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分子量
- approx. 32 kDa
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基因ID
- 9973
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NCBI登录号
- NP_005116
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UniProt
- O14618
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途径
- Transition Metal Ion Homeostasis
抗原
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