H2AFX 抗体 (pSer139)
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- 抗原 See all H2AFX 抗体
- H2AFX (H2A Histone Family, Member X (H2AFX))
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抗原表位
- pSer139
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This H2AFX antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of Histone H2A.X protein only when phophorylated at Serine 139.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product H2AFX Primary Antibody
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anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) antibodyH2AFX 适用: 人 WB, IHC, ELISA, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibodyH2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 938CT5-1-1 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibodyH2AFX 适用: 人 WB, ELISA, IHC (p), FACS, ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibodyH2AFX 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) antibodyH2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 8C5 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX 适用: 人 WB, ELISA, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibodyH2AFX 适用: 人 WB, IF, ICC, ChIP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- H2AFX (H2A Histone Family, Member X (H2AFX))
- 别名
- Histone H2A.x (H2AFX 产品)
- 别名
- H2A.X antibody, H2A/X antibody, H2AX antibody, AW228881 antibody, H2ax antibody, Hist5-2ax antibody, gammaH2ax antibody, zgc:56329 antibody, h2a.x antibody, h2a/x antibody, h2ax antibody, RGD1566119 antibody, h2a antibody, h2afx antibody, H2A histone family member X antibody, H2A histone family, member X antibody, H2A histone family member X L homeolog antibody, histone cluster 1, H2ah antibody, histone cluster 2, H2ab S homeolog antibody, histone H2AX antibody, H2AFX antibody, H2afx antibody, h2afx antibody, h2afx.L antibody, HIST1H2AH antibody, hist2h2ab.S antibody, LOC100522201 antibody, LOC100720536 antibody
- 背景
- Histone H2A.X is a member of the Histone H2A family, which is involved in nucleosomal organization of chromatin. The Histone H2A.X gene is located in close proximity to the porphobilinogen deaminase (PBGD) gene in both mouse and human, and maps to 9 A5.2 and 11q23.3, respectively. H2A.X differs from the other members of the H2A family by the presence of a highly conserved C-terminal motif. It is rapidly phosphorylated in response to ionizing radiation and plays an important role in the recognition and repair of DNA double stranded breaks. The phosphorylated form of H2A.X, designated γ-H2A.X, forms nuclear foci at the heavy chain constant region of cells involved in class switch recombination (CSR), a region-specific DNA reaction that replaces one immunoglobulin heavy chain constant region gene with another. The phosphorylated gamma-H2A.X is also thought to initiate subsequent repair factors, including Rad50, Rad51 and BRCA1.Synonyms: H2AFX, H2AX, H2a/x
- 分子量
- approx. 15 kDa
- 基因ID
- 3014
- NCBI登录号
- NP_002096
- UniProt
- P16104
- 途径
- Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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