CTNNB1 抗体 (pSer37)
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Quick Overview for CTNNB1 抗体 (pSer37) (ABIN498725)
抗原
See all CTNNB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer37
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特异性
- This antibody detects endogenous levels of Catenin-beta protein only when phosphorylated at Ser37.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (N-Term) antibody
KO Validated CTNNB1 适用: 人 WB, IHC, IF, FACS, IHC (p), IP, ICC, IHC (fro), ChIP, CUT&RUN, IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (N-Term) antibodyCTNNB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 692-721), (C-Term) antibodyCTNNB1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB41124 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 大鼠, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 12H7 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 9C1 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1E10 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 大鼠, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 9H2 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 6A3 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 682-781) antibodyCTNNB1 适用: 人 WB, ELISA, IF, PLA, RNAi 宿主: 小鼠 Monoclonal 1C9 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyCTNNB1 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, Hamster WB, IHC, IF, FACS 宿主: 兔 Monoclonal CTNNB1-2030R unconjugated Recombinant Antibody
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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别名
- Catenin beta-1
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背景
- The catenins, alpha, beta and gamma, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3beta, result in accumulation of the beta-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of beta-catenin signaling that directly binds a phosphorylated Ser- Pro motif next to the APC-binding site in beta-catenin, inhibiting the interaction with APC and increasing beta-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of beta-catenin in tumors such as breast cancer.Synonyms: Beta-catenin, CTNNB, CTNNB1
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分子量
- approx. 92 kDa
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基因ID
- 1499
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NCBI登录号
- NP_001091679
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UniProt
- P35222
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途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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