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SNAIL 抗体 (pSer246)

The 兔 多克隆 anti-SNAIL antibody (ABIN498696) specifically detects SNAIL in WB, IF 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN498696
发货至: 中国
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Quick Overview for SNAIL 抗体 (pSer246) (ABIN498696)

抗原

See all SNAIL (SNAI1) 抗体
SNAIL (SNAI1)

适用

  • 85
  • 40
  • 19
  • 7
  • 3
  • 3
  • 3
  • 1
  • 1
人, 小鼠

宿主

  • 71
  • 12
  • 3
  • 2

克隆类型

  • 76
  • 12
多克隆

标记

  • 64
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This SNAIL antibody is un-conjugated

应用范围

  • 65
  • 43
  • 32
  • 21
  • 12
  • 5
  • 5
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 14
    • 11
    • 10
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer246

    特异性

    This antibody detects endogenous levels of p-SNAI 1 protein, only when phosphorylated at Ser246.

    交叉反应 (详细)

    Species reactivity (tested):Human, Mouse.

    纯化方法

    Affinity chromatography

    纯度

    > 95 % by SDS-PAGE
  • 应用备注

    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1,0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    SNAIL (SNAI1)

    别名

    SNAI1

    背景

    The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of DrosophilaSNAIL,and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna,each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1

    分子量

    approx. 29 kDa

    基因ID

    6615

    NCBI登录号

    NP_005976

    UniProt

    O95863

    途径

    Negative Regulation of intrinsic apoptotic Signaling
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