SNAIL 抗体 (pSer246)
Our Local Distributor
北京 101111
Quick Overview for SNAIL 抗体 (pSer246) (ABIN498696)
抗原
See all SNAIL (SNAI1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer246
-
特异性
- This antibody detects endogenous levels of p-SNAI 1 protein, only when phosphorylated at Ser246.
-
交叉反应 (详细)
- Species reactivity (tested):Human, Mouse.
-
纯化方法
- Affinity chromatography
-
纯度
- > 95 % by SDS-PAGE
-
-
-
-
应用备注
-
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1,0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- SNAIL (SNAI1)
-
别名
- SNAI1
-
背景
- The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of DrosophilaSNAIL,and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna,each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
-
分子量
- approx. 29 kDa
-
基因ID
- 6615
-
NCBI登录号
- NP_005976
-
UniProt
- O95863
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-