ABL1 抗体
Our Local Distributor
北京 101111
Quick Overview for ABL1 抗体 (ABIN498594)
抗原
See all ABL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- This antibody detects endogenous levels of c-Abl protein. (region surrounding Leu406)
-
交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
-
纯化方法
- Affinity chromatography using epitope-specific immunogen
-
纯度
- > 95 % (by SDS-PAGE)
-
-
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 490-590) antibody
ABL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr251) antibodyABL1 适用: 人 WB, IF, IHC (p), DB 宿主: 兔 Polyclonal RB7351 unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr245) antibodyABL1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr412) antibodyABL1 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr393), (pTyr412) antibodyABL1 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 850-900) antibodyABL1 适用: 人 IHC, ICC, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 741-769) antibodyABL1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr204) antibodyABL1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr393), (pTyr439) antibodyABL1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 741-769) antibodyABL1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB15710 unconjugated
-
-
应用备注
-
Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
-
-
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
-
别名
- ABL1
-
背景
- The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95 % of chronic myelocytic leukemia (CML), 20-25 % of adult acute lymphoblastic leukemia (ALL) and 2-5 % of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.Synonyms: Abelson murine leukemia viral oncogene homolog 1, JTK7, Proto-oncogene tyrosine-protein kinase ABL1, bcr/abl, c-ABL, p150
-
分子量
- approx. 123 kDa
-
基因ID
- 25
-
NCBI登录号
- NP_005148
-
UniProt
- P00519
-
途径
- Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
抗原
-
