GZMK 抗体
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Quick Overview for GZMK 抗体 (ABIN498383)
抗原
See all GZMK 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Granzyme K protein. (region surrounding His85)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (Internal Region) antibody
GZMK 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (AA 27-264) antibodyGZMK 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) antibodyGZMK 适用: 人 ELISA, FACS, cELISA 宿主: 小鼠 Monoclonal GM-24C3 unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (AA 44-227) antibodyGZMK 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (AA 61-110) antibodyGZMK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) antibodyGZMK 适用: 人 ELISA, FACS, cELISA 宿主: 小鼠 Monoclonal GM-26E7 unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (AA 87-121) antibodyGZMK 适用: 人 WB 宿主: 兔 Polyclonal RB52998 unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (AA 1-264) antibodyGZMK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (Internal Region) antibodyGZMK 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) (Internal Region) antibodyGZMK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))
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别名
- Granzyme K (GZMK)
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背景
- The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H localizes to cytoplasmic granules of cytolytic T lymphocytes and is important for target cell lysis in cell-mediated immune responses. Granzyme K (GMZK), also designated granzyme-3 or NK-tryptase-2 (NK-TRYP-2), contains one peptidase S1 domain. Granzyme K is a serine protease localizing to the granules of natural killer cells and cytotoxic T lymphocytes. It is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.Synonyms: Fragmentin-3, Granzyme-3, NK-Tryp-2, NK-tryptase-2, TRYP2
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分子量
- approx. 33 kDa
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基因ID
- 3003
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NCBI登录号
- NP_002095
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UniProt
- P49863
抗原
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