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BHLHE41 抗体

The 兔 多克隆 anti-BHLHE41 antibody is suitable to detect BHLHE41 in samples from 人, 小鼠 和 大鼠. It has been validated for WB 和 IHC (p).
产品编号 ABIN498356
发货至: 中国
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Quick Overview for BHLHE41 抗体 (ABIN498356)

抗原

See all BHLHE41 抗体
BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

适用

  • 45
  • 24
  • 16
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 35
  • 9
  • 1

克隆类型

  • 37
  • 8
多克隆

标记

  • 29
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This BHLHE41 antibody is un-conjugated

应用范围

  • 33
  • 21
  • 8
  • 7
  • 6
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody detects endogenous levels of DEC2 protein. (region surrounding Lys31)

    交叉反应 (详细)

    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography

    纯度

    > 95 % by SDS-PAGE
  • 应用备注

    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1,0 mg/mL

    缓冲液

    PBS, pH ~7.3, 0.05 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

    别名

    BHLHB3 / BHLHE41

    背景

    Human DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy, and Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner.Synonyms: Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, DEC2, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1, SHARP-1, SHARP1

    分子量

    approx. 50 kDa

    基因ID

    79365

    NCBI登录号

    NP_110389

    UniProt

    Q9C0J9

    途径

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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