KSR2 抗体
Quick Overview for KSR2 抗体 (ABIN498345)
抗原
See all KSR2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Kinase suppressor of Ras 2. (region surrounding Ile694)
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交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Kinase Suppressor of Ras 2 (KSR2) (AA 411-500) antibody
KSR2 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (AA 411-500) antibodyKSR2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 6C9 unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) antibodyKSR2 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (AA 159-296) antibodyKSR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (AA 411-500) antibodyKSR2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (Internal Region) antibodyKSR2 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (AA 603-638), (C-Term) antibodyKSR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB09886 unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (C-Term) antibodyKSR2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (Ile694) antibodyKSR2 适用: 人, 小鼠 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 2 (KSR2) (AA 411-500) antibodyKSR2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 6F12 unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % Sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- KSR2 (Kinase Suppressor of Ras 2 (KSR2))
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别名
- Kinase Suppressor of Ras 2
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背景
- Kinase suppressor of Ras (KSR) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr-1 and Ksr-2. These two are individually necessary for a few specific Ras-dependent processes, but they are required together for most aspects of Ras-mediated signaling. Ksr-2 plays a key role in Ras-mediated signaling during germline meiotic progression and functions redundantly with Ksr-1 during the development of the excretory system pathway, hermaphrodite vulva and male spicules. Ksr-2 also functions as a negative regulator of the MEKK3-mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NFκB pathways, and it simultaneously inhibits MEKK3-mediated IL-8 production.Synonyms: KSR-2, KSR2, hKSR-2, hKSR2
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分子量
- approx. 108 kDa
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基因ID
- 283455
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NCBI登录号
- NP_775869
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UniProt
- Q6VAB6
抗原
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