CBFB 抗体
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北京 101111
Quick Overview for CBFB 抗体 (ABIN498340)
抗原
See all CBFB 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PEBP2beta protein. (region surrounding Arg33)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-187) antibody
CBFB 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-182) antibodyCBFB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (Internal Region) antibodyCBFB 适用: 人 ELISA, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (N-Term) antibodyCBFB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 61-90) antibodyCBFB 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB21198 unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) antibodyKD Validated CBFB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3785 unconjugated Recombinant Antibody
anti-Core-Binding Factor, beta Subunit (CBFB) antibodyCBFB 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) antibodyCBFB 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 344C3a unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 74-163) antibodyCBFB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 166-187), (Isoform 1) antibodyCBFB 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CBFB (Core-Binding Factor, beta Subunit (CBFB))
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别名
- CBFB
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背景
- The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, alpha and beta, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2alpha subunits, PEBP2alphaA, PEBP2alphaB and PEBP2alphaC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory beta subunit, which facilitates DNA binding of the alpha subunit. Both subunits are required for in vivo function, the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2beta is the target of chromosomal inversion 16 (p13,q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2beta/CBFbeta-SMMHC, that is associated with human acute myeloid leukemia.Synonyms: CBF beta, CBF-beta, Core-binding factor beta, PEA2-beta, PEBP2-beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
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分子量
- approx. 22 kDa
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基因ID
- 865
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NCBI登录号
- NP_001746
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UniProt
- Q13951
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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