TNFSF9 抗体
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北京 101111
Quick Overview for TNFSF9 抗体 (ABIN498281)
抗原
See all TNFSF9 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of 4-1BBL protein. (region surrounding Arg69)
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交叉反应 (详细)
- Species reactivity (tested):Human.
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纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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别名
- 4-1BBL / TNFSF9
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背景
- CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of CD137 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.Synonyms: 4-1BB ligand, CD137L, Tumor necrosis factor ligand superfamily member 9
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分子量
- approx. 23 kDa
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基因ID
- 8744
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NCBI登录号
- NP_003802
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UniProt
- P41273
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途径
- Activated T Cell Proliferation, Cancer Immune Checkpoints
抗原
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