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SSB 抗体

This anti-SSB antibody is a 兔 多克隆 antibody detecting SSB in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN498215
发货至: 中国

Quick Overview for SSB 抗体 (ABIN498215)

抗原

See all SSB 抗体
SSB (Sjogren Syndrome Antigen B (SSB))

适用

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宿主

  • 79
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克隆类型

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多克隆

标记

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This SSB antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody detects endogenous levels of SSB protein.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography using epitope-specific immunogen

    纯度

    > 95 % (by SDS-PAGE)
  • 应用备注

    Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    SSB (Sjogren Syndrome Antigen B (SSB))

    别名

    SS-B / La

    背景

    Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex, thereby mediating protein degradation. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. SSB-2 (SplA/ryanodine (SPRY) receptor domain-containing SOCS box protein 2), also known as GGRCC9 (gene-rich cluster protein C9), SPSB2 or MGC2519, is a cytoplasmic protein belonging to the SPSB family of proteins that contain a central SPRY domain and a C-terminal SOCS box. The SPRY domain is believed to be a protein-protein interaction motif. Members of the SPSB family are capable of interacting with Met (a receptor for hepatocyte growth factors (HGFs)), and SSB-1 is known to promote HGF signaling. SSB-1, SSB-2 and SSB-4 are also able to interact with PAR4 (prostate apoptosis response protein 4). Mutations in the genes encoding SPSB proteins are associated with several human diseases.Synonyms: LARP3, La autoantigen, La ribonucleoprotein, Lupus La protein, SSB, Sjoegren syndrome type B antigen

    分子量

    approx. 50 kDa

    基因ID

    6741

    NCBI登录号

    NP_003133

    UniProt

    P05455
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