ATG10 抗体 (C-Term)
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北京 101111
Quick Overview for ATG10 抗体 (C-Term) (ABIN497986)
抗原
See all ATG10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Recognizes APG10L/ATG10 (C-term).
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交叉反应 (详细)
- Species reactivity (tested):Human, Mouse and Rat
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- ATG10 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of Human ATG10 (Genbank accession No. EAW95884).
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亚型
- IgG
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应用备注
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ELISA. Western blot: ATG10 antibody can be used for the detection of ATG10 at 0.5-1 μg/mL. Positive Control: SK-N-SH Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.
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- ATG10 (Autophagy Related 10 (ATG10))
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别名
- APG10L / ATG10
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背景
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy protein family is ATG10, an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjugation and the modification of a soluble form of MAP-LC3, a homolog of yeast Apg8, to a membrane-bound form. ATG10 has also been shown to interact with ATG12 in human embryonic kidney cells in the presence of ATG7. Multiple isoforms of ATG10 are known to exist.Synonyms: Autophagy-related protein 10
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基因ID
- 83734
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NCBI登录号
- NP_001124500
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UniProt
- Q9H0Y0
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途径
- ER-Nucleus Signaling, Autophagy
抗原
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