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FLT4 抗体

This anti-FLT4 antibody is a 小鼠 单克隆 antibody detecting FLT4 in WB, IHC, ELISA 和 FACS. Suitable for 人.
产品编号 ABIN3030977
发货至: 中国

Quick Overview for FLT4 抗体 (ABIN3030977)

抗原

See all FLT4 抗体
FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This FLT4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

克隆位点

818CT12-1-1
  • 纯化方法

    Purified

    免疫原

    Purified His-tagged protein was used to produced this monoclonal VEGFR3 antibody.

    亚型

    IgG2a
  • 应用备注

    Titration of the VEGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,IHC (Paraffin): 1:25,Western blot: 1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the VEGFR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

    别名

    VEGFR3

    背景

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

    UniProt

    P35916

    途径

    RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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