TLR5 抗体 (AA 71-102)
Our Local Distributor
北京 101111
Quick Overview for TLR5 抗体 (AA 71-102) (ABIN3029172)
抗原
See all TLR5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 71-102
-
纯化方法
- Purified
-
免疫原
- A portion of amino acids 71-102 from the mouse protein was used as the immunogen for this TLR5 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the TLR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the TLR5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- TLR5 (Toll-Like Receptor 5 (TLR5))
-
别名
- TLR5
-
背景
- TLR5, a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. It also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5.
-
UniProt
- Q9JLF7
-
途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
-