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STUB1 抗体 (AA 203-231)

This anti-STUB1 antibody is a 兔 多克隆 antibody detecting STUB1 in WB, ELISA 和 IHC. Suitable for 人.
产品编号 ABIN3032755
发货至: 中国

Quick Overview for STUB1 抗体 (AA 203-231) (ABIN3032755)

抗原

See all STUB1 抗体
STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

适用

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宿主

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克隆类型

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多克隆

标记

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This STUB1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 203-231

    交叉反应 (详细)

    Expected species reactivity: Mouse, Chicken

    纯化方法

    Antigen affinity purified

    免疫原

    A portion of amino acids 203-231 from the human protein was used as the immunogen for this STUB1 antibody.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the STUB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS pH 7.4 with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the STUB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

    别名

    STUB1

    背景

    CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.

    UniProt

    Q9UNE7

    途径

    Regulation of Hormone Metabolic Process, Response to Water Deprivation
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