PTEN 抗体 (AA 264-295)
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北京 101111
Quick Overview for PTEN 抗体 (AA 264-295) (ABIN3032215)
抗原
See all PTEN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 264-295
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纯化方法
- Purified
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免疫原
- A portion of amino acids 264-295 from the human protein was used as the immunogen for this PTEN antibody.
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亚型
- Ig Fraction
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anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibodyPTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibodyPTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibodyPTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 10-44), (N-Term) antibodyPTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pSer385) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39440 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pTyr176) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39742 unconjugated
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应用备注
- Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PTEN (Phosphatase and Tensin Homolog (PTEN))
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别名
- PTEN
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背景
- PTEN (phosphatase and tensin homolog deleted on chromosome 10) acts as a tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. [UniProt]
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UniProt
- P60484
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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