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Retinoblastoma Protein (Rb) 抗体 (pSer788)

This anti-Retinoblastoma Protein (Rb) antibody is a 兔 多克隆 antibody detecting Retinoblastoma Protein (Rb) in ELISA, IHC 和 DB. Suitable for 人.
产品编号 ABIN3032467
发货至: 中国

Quick Overview for Retinoblastoma Protein (Rb) 抗体 (pSer788) (ABIN3032467)

抗原

See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体
Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

适用

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宿主

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克隆类型

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多克隆

标记

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This Retinoblastoma Protein (Rb) antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC), Dot Blot (DB)
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    pSer788

    纯化方法

    Antigen affinity purified

    免疫原

    This phospho-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS788 of human Rb.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the phospho-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the phospho-Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

    别名

    Retinoblastoma / Rb

    背景

    RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.

    UniProt

    P06400

    途径

    Mitotic G1-G1/S Phases
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