Retinoblastoma Protein (Rb) 抗体 (pSer788)
Quick Overview for Retinoblastoma Protein (Rb) 抗体 (pSer788) (ABIN3032467)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer788
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS788 of human Rb.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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别名
- Retinoblastoma / Rb
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背景
- RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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