PTEN 抗体 (pTyr315)
Quick Overview for PTEN 抗体 (pTyr315) (ABIN3032211)
抗原
See all PTEN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr315
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交叉反应 （详细）
- Expected species reactivity: Mouse
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY315 of human PTEN.
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亚型
- Ig Fraction
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anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibodyPTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibodyPTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibodyPTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 10-44), (N-Term) antibodyPTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pSer385) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39440 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated
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应用备注
- Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PTEN (Phosphatase and Tensin Homolog (PTEN))
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别名
- PTEN
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背景
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
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UniProt
- P60484
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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