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MAP2 抗体 (pSer1539)

This anti-MAP2 antibody is a 兔 多克隆 antibody detecting MAP2 in ELISA 和 DB. Suitable for 人.
产品编号 ABIN3031685
发货至: 中国

Quick Overview for MAP2 抗体 (pSer1539) (ABIN3031685)

抗原

See all MAP2 抗体
MAP2 (Microtubule-Associated Protein 2 (MAP2))

适用

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宿主

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克隆类型

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多克隆

标记

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This MAP2 antibody is un-conjugated

应用范围

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ELISA, Dot Blot (DB)
  • 抗原表位

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    pSer1539

    交叉反应 (详细)

    Expected species reactivity: Mouse, Rat

    纯化方法

    Antigen affinity purified

    免疫原

    This phospho-MAP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1539 of human MAP2.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the phospho-MAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS pH 7.4 with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the phospho-MAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    MAP2 (Microtubule-Associated Protein 2 (MAP2))

    别名

    MAP2

    背景

    MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

    UniProt

    P11137
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