c-FOS 抗体 (pThr232)
Quick Overview for c-FOS 抗体 (pThr232) (ABIN3030222)
抗原
See all c-FOS (c-Fos) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr232
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-c-Fos antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT232 of the human protein.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho-c-Fos antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-c-Fos antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- c-FOS (c-Fos) (c-Fos)
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别名
- C-Fos
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背景
- C-Fos is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. [UniProt]
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UniProt
- P01100
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途径
- S100 Proteins
抗原
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