c-MYC 抗体 (pThr58)
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Quick Overview for c-MYC 抗体 (pThr58) (ABIN3029537)
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr58
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交叉反应 (详细)
- Expected species reactivity: Bovine, Chicken, Mouse, Pig, Rat, Xenopus, Zebrafish
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho c-Myc antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT58 of human MYC.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho c-Myc antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho c-Myc antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
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别名
- C-Myc
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背景
- C-Myc participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
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UniProt
- P01106
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途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
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