LIN28A 抗体 (AA 108-138)
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北京 101111
Quick Overview for LIN28A 抗体 (AA 108-138) (ABIN3031626)
抗原
See all LIN28A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 108-138
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纯化方法
- Purified
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免疫原
- A portion of amino acids 108-138 from the human protein was used as the immunogen for this LIN28A antibody.
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亚型
- Ig Fraction
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anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 108-138) antibody
LIN28A 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB14827 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (N-Term) antibodyLIN28A 适用: 人, Cow, 犬, Pig, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 93-209) antibodyLIN28A 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 6D1F9 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 142-209) antibodyLIN28A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 168-198), (C-Term) antibodyLIN28A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14266 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 177-210), (C-Term) antibodyLIN28A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51168 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) antibodyKD Validated LIN28A 适用: 人 WB 宿主: 兔 Monoclonal 25GB2520 unconjugated Recombinant Antibody
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:100,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
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别名
- LIN28A
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背景
- Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
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UniProt
- Q9H9Z2
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途径
- Stem Cell Maintenance
抗原
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