Kdm6b 抗体 (AA 1-30)
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北京 101111
Quick Overview for Kdm6b 抗体 (AA 1-30) (ABIN3031660)
抗原
See all Kdm6b 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-30
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交叉反应 （详细）
- Expected species reactivity: Mouse
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纯化方法
- Purified
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免疫原
- A portion of amino acids 1-30 from the human protein was used as the immunogen for this JMJD3 antibody.
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亚型
- Ig Fraction
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anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 265-450) antibody
Kdm6b 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1-30), (N-Term) antibodyKdm6b 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB10077 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1606-1641), (C-Term) antibodyKdm6b 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB10081-RB10082 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1530-1682) antibodyKdm6b 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1023-1057) antibodyKdm6b 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50943 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 879-912) antibodyKdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51280 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1613-1662) antibodyKdm6b 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibodyKdm6b 适用: 人, 大鼠, 犬, Cow, 马, 兔, 猴, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (Middle Region) antibodyKdm6b 适用: 人, 小鼠, 大鼠, 犬, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibodyKdm6b 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the JMJD3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the JMJD3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
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别名
- JMJD3 (KDM6B)
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背景
- Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
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UniProt
- O15054
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途径
- Warburg Effect
抗原
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