Kdm6b 抗体 (N-Term)
(15 references)-
- 抗原 See all Kdm6b 抗体
- Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
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抗原表位
- AA 1-30, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Kdm6b antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- M
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD3.
- 克隆位点
- RB10077
- 亚型
- Ig Fraction
- Top Product
- Discover our top product Kdm6b Primary Antibody
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anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 265-450) antibody
Kdm6b 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1-30) antibodyKdm6b 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibodyKdm6b 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1606-1641), (C-Term) antibodyKdm6b 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB10081-RB10082 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1530-1682) antibodyKdm6b 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1023-1057) antibodyKdm6b 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50943 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 879-912) antibodyKdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51280 unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibodyKdm6b 适用: 人, 大鼠, 犬, 兔, Cow, 马, 猴, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1613-1662) antibodyKdm6b 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1161-1350) antibodyKdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze-thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
- 有效期
- 6 months
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: "Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells." in: PLoS ONE, Vol. 11, Issue 6, pp. e0156671, (2017) (PubMed).
: "Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification." in: Cell reports, Vol. 19, Issue 2, pp. 295-306, (2017) (PubMed).
: "Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer." in: International journal of oncology, Vol. 46, Issue 4, pp. 1788-800, (2015) (PubMed).
: "Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma." in: Nature medicine, (2014) (PubMed).
: "Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury." in: Journal of neurochemistry, Vol. 122, Issue 2, pp. 272-82, (2013) (PubMed).
: "Histone demethylase KDM6B promotes epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 287, Issue 53, pp. 44508-17, (2012) (PubMed).
: "Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells." in: Molecular pharmacology, Vol. 80, Issue 5, pp. 870-8, (2011) (PubMed).
: "Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes." in: Journal of virology, Vol. 85, Issue 21, pp. 10999-1006, (2011) (PubMed).
: "Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs." in: Developmental biology, Vol. 357, Issue 2, pp. 492-504, (2011) (PubMed).
: "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 8719-32, (2010) (PubMed).
: "Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells." in: Journal of cellular biochemistry, Vol. 110, Issue 6, pp. 1457-63, (2010) (PubMed).
: "Epigenetic analysis of KSHV latent and lytic genomes." in: PLoS pathogens, Vol. 6, Issue 7, pp. e1001013, (2010) (PubMed).
: "Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 42, Issue 6, pp. 911-20, (2010) (PubMed).
: "Abnormal expression pattern of histone demethylases in CD4(+) T cells of MRL/lpr lupus-like mice." in: Lupus, Vol. 18, Issue 14, pp. 1327-8, (2009) (PubMed).
: "Epigenetic regulation of the alternatively activated macrophage phenotype." in: Blood, Vol. 114, Issue 15, pp. 3244-54, (2009) (PubMed).
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: "Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells." in: PLoS ONE, Vol. 11, Issue 6, pp. e0156671, (2017) (PubMed).
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- 抗原
- Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
- 别名
- JMJD3 (Kdm6b 产品)
- 别名
- jmjd3 antibody, kdm6b antibody, si:ch211-237l4.7 antibody, 1700064E03Rik antibody, BC038313 antibody, Jmjd3 antibody, mKIAA0346 antibody, JMJD3 antibody, lysine (K)-specific demethylase 6B antibody, lysine demethylase 6B antibody, lysine (K)-specific demethylase 6B, b antibody, KDM1 lysine (K)-specific demethylase 6B antibody, kdm6b antibody, KDM6B antibody, kdm6bb antibody, Kdm6b antibody
- 背景
- Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
- 分子量
- 176632
- 基因ID
- 23135
- NCBI登录号
- NP_001073893
- UniProt
- O15054
- 途径
- Warburg Effect
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