IRF9 抗体 (AA 75-104)
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北京 101111
Quick Overview for IRF9 抗体 (AA 75-104) (ABIN3031426)
抗原
See all IRF9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-104
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 75-104 from the human protein was used as the immunogen for this IRF9 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the IRF9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the IRF9 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- IRF9 (Interferon Regulatory Factor 9 (IRF9))
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别名
- IRF9
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背景
- IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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UniProt
- Q00978
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途径
- JAK/STAT Signaling, Interferon-gamma Pathway, Hepatitis C
抗原
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