EPH Receptor B1 抗体 (AA 374-409)
Quick Overview for EPH Receptor B1 抗体 (AA 374-409) (ABIN3030823)
抗原
See all EPH Receptor B1 (EPHB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 374-409
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交叉反应 （详细）
- Expected species reactivity: Chicken
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 374-409 from the mouse protein were used as the immunogen for the Ephb1 antibody.
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亚型
- Ig Fraction
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anti-EPH Receptor B1 (EPHB1) (AA 955-984), (C-Term) antibody
EPHB1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1648 unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 221-320) antibodyEPHB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-EPH Receptor B1 (EPHB1) (pTyr594), (pTyr604) antibodyEPHB1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 374-409) antibodyEPHB1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50839 unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 260-500) antibodyEPHB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 485-497), (Extracellular) antibodyEPHB1 适用: 小鼠 WB, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (pTyr928) antibodyEPHB1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (C-Term) antibodyEPHB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 260-500) antibodyEPHB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 620-1596) antibodyEPHB1 适用: 人 WB, IHC, IP 宿主: 绵羊 Polyclonal unconjugated
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应用备注
- Titration of the Ephb1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Ephb1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- EPH Receptor B1 (EPHB1)
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别名
- Ephb1
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背景
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
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UniProt
- Q8CBF3
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途径
- RTK signaling
抗原
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