DNMT3B 抗体 (AA 389-417)
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Quick Overview for DNMT3B 抗体 (AA 389-417) (ABIN3030752)
抗原
See all DNMT3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 389-417
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纯化方法
- Purified
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免疫原
- A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Dnmt3b antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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别名
- Dnmt3b
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背景
- CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.
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UniProt
- Q9UBC3
抗原
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