DNMT1 抗体 (AA 881-914)
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Quick Overview for DNMT1 抗体 (AA 881-914) (ABIN3030755)
抗原
See all DNMT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 881-914
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 881-914 from the mouse protein was used as the immungen for the Dnmt1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Dnmt1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500-1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Dnmt1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
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别名
- Dnmt1
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背景
- Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. Three families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.
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UniProt
- P13864
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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