DCLK2 抗体 (AA 167-196)
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Quick Overview for DCLK2 抗体 (AA 167-196) (ABIN3030772)
抗原
See all DCLK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 167-196
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 167-196 from the human protein was used as the immunogen for this DCLK2 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the DCLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the DCLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))
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别名
- DCLK2
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背景
- This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
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UniProt
- Q8N568
抗原
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