DCLK1 抗体 (AA 153-181)
Our Local Distributor
北京 101111
Quick Overview for DCLK1 抗体 (AA 153-181) (ABIN3030771)
抗原
See all DCLK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 153-181
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 153-181 from the mouse protein was used as the immunogen for this Dclk1 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the Dclk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the Dclk1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
-
别名
- Dclk1
-
背景
- This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
-
UniProt
- Q9JLM8
抗原
-