CPT1C 抗体 (AA 596-625)
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Quick Overview for CPT1C 抗体 (AA 596-625) (ABIN3030284)
抗原
See all CPT1C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 596-625
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 596-625 from the human protein was used as the immunogen for this CPT1C antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the CPT1C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the CPT1C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))
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别名
- CPT1C
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背景
- The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.
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UniProt
- Q8TCG5
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途径
- AMPK Signaling, Monocarboxylic Acid Catabolic Process
抗原
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