Androgen Receptor 抗体 (AA 475-504)
Quick Overview for Androgen Receptor 抗体 (AA 475-504) (ABIN3029943)
抗原
See all Androgen Receptor (AR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 475-504
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 475-504 from the human protein was used as the immunogen for this AR antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Androgen Receptor (AR)
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别名
- AR
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背景
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The androgen receptor, also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. It is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.
The main function of the AR is as a DNA-binding transcription factor that regulates gene expression, however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. [Wiki] -
UniProt
- P10275
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途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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