APP 抗体 (AA 333-362)
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Quick Overview for APP 抗体 (AA 333-362) (ABIN3029927)
抗原
See all APP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 333-362
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 333-362 from the human protein was used as the immunogen for this anti-APP antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the anti-APP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the anti-APP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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别名
- APP
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背景
- The APP gene encodes Amyloid beta, a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
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UniProt
- P05067
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途径
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
抗原
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