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- 抗原 See all Desmoglein 2 (DSG2) 抗体
- Desmoglein 2 (DSG2)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Desmoglein 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- A recombinant human DSG2 protein was used as the immunogen for the Desmoglein 2 antibody.
- 克隆位点
- 6D8
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product DSG2 Primary Antibody
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anti-Desmoglein 2 (DSG2) antibody
DSG2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 72-121) antibodyDSG2 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人, 大鼠, 小鼠, Cow, 犬, Pig, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 275-533) antibodyDSG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 183-331) antibodyDSG2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 37-164) antibodyDSG2 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 10D2 unconjugated
anti-Desmoglein 2 (DSG2) (AA 51-150) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) antibodyDSG2 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 6D8 unconjugated
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- 应用备注
- Optimal dilution of the Desmoglein 2 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,WB: 1-2 μg/mL,Immunoprecipitation: suitable
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- 储存液
- Azide free
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the Desmoglein 2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- Desmoglein 2 (DSG2)
- 别名
- Desmoglein 2 / DSG2 (DSG2 产品)
- 别名
- DSG2 antibody, dsc antibody, dsga antibody, si:dkeyp-51f12.6 antibody, wu:fj23f02 antibody, ARVC10 antibody, ARVD10 antibody, CDHF5 antibody, CMD1BB antibody, HDGC antibody, AA408168 antibody, D18Ertd293e antibody, desmoglein 2 antibody, desmoglein 2, tandem duplicate 1 antibody, DSG2 antibody, dsg2.1 antibody, dsg2 antibody, Dsg2 antibody
- 背景
- Recognizes a protein of 165 kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, desmogleins have R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tails of desmogleins interact with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the desmogleins with the intermediate filaments. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. Desmoglein2 was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon).
- 途径
- Cell-Cell Junction Organization
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