GJB1 抗体 (Cytoplasmic Loop)
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Quick Overview for GJB1 抗体 (Cytoplasmic Loop) (ABIN4949578)
抗原
See all GJB1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- Cytoplasmic Loop
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原理
- Connexin 32 Antibody / GJB1 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- Rat junctional complexes were used as the immunogen for the Connexin 32 antibody. The epitope is known to be located in the cytoplasmic loop (Ref 1).
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亚型
- IgG
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应用备注
- Optimal dilution of the Connexin 32 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Connexin 32 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- GJB1 (Gap Junction Protein, beta 1, 32kDa (GJB1))
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别名
- Connexin 32
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背景
- This Ab recognizes a protein of 27-32 kDa, identified as Connexin 32. The connexin family of proteins forms hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α,-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20-connexin isoforms produces channels with distinct permeability and electrical and chemical sensitivities, therefore, one connexin usually cannot fully substitute for another.
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UniProt
- P08034
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途径
- Cell-Cell Junction Organization
抗原
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