BAFF 抗体
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北京 101111
Quick Overview for BAFF 抗体 (ABIN4949453)
抗原
See all BAFF (TNFSF13B) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant human BAFF protein was used as the immunogen for this BAFF antibody.
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亚型
- IgG1
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应用备注
- Titering of the BAFF antibody may be required for optimal performance.\. FACS: 0.5-1 μg/million cells,IF: 1-2 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in sterile PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- BAFF antibody with azide can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
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别名
- BAFF / BLyS
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背景
- BAFF/BLyS/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31 kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).
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途径
- NF-kappaB Signaling, Production of Molecular Mediator of Immune Response
抗原
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