Aurora Kinase B 抗体 (AA 89-251)
Quick Overview for Aurora Kinase B 抗体 (AA 89-251) (ABIN4949412)
抗原
See all Aurora Kinase B (AURKB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 89-251
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纯化方法
- Protein G affinity
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免疫原
- Amino acids 89-251 were used as the immunogen for this Aurora B antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the Aurora B antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,FACS: 0.5-1 μg/10e6 cells in 0.1ml,IF: 1-2 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Aurora B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Aurora Kinase B (AURKB)
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别名
- Aurora B / AURKB
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背景
- Recognizes a protein of 39-45 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
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途径
- TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
抗原
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