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USP5 抗体

This anti-USP5 antibody is a 小鼠 单克隆 antibody detecting USP5 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN4915071
发货至: 中国

Quick Overview for USP5 抗体 (ABIN4915071)

抗原

See all USP5 抗体
USP5 (Ubiquitin Specific Peptidase 5 (USP5))

适用

  • 41
  • 6
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 34
  • 8
小鼠

克隆类型

  • 34
  • 8
单克隆

标记

  • 27
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This USP5 antibody is un-conjugated

应用范围

  • 28
  • 19
  • 10
  • 5
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

克隆位点

13C4
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

    亚型

    IgG1
  • 应用备注

    WB 1:300-5000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    USP5 (Ubiquitin Specific Peptidase 5 (USP5))

    别名

    USP5

    背景

    Synonyms: ISOT, Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, USP 5, USP-5

    Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

    基因ID

    8078

    UniProt

    P45974
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