TLR4 抗体 (AA 121-200)
Quick Overview for TLR4 抗体 (AA 121-200) (ABIN4914683)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 121-200
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特异性
- Mouse TLR4 has 75 % homology to the antibody immunogen sequence
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Cow,Sheep,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human TLR4
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亚型
- IgG
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anti-Toll-Like Receptor 4 (TLR4) (AA 751-835) antibody
TLR4 适用: 人, 小鼠, 大鼠, Cow WB, FACS, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibodyTLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 49-247) antibodyTLR4 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (HRP)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal HRP
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (FITC)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal FITC
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Biotin)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PE)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PE
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (APC)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal APC
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (PerCP)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal PerCP
anti-Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody (Atto 488)TLR4 适用: 人 WB, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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别名
- TLR4
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背景
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Synonyms: Toll-like receptor 4, TLR4, CD284
Background: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed:23880187).
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基因ID
- 7099
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UniProt
- O00206
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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