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- 抗原 See all RAP1 (TERF2IP) 抗体
- RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This RAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
- 交叉反应
- 人
- 纯化方法
- Purified by Protein G.
- 免疫原
- This TERF2IP antibody is generated from a mouse immunized with a recombinant protein from human TERF2IP.
- 克隆位点
- 4C8
- 亚型
- IgG1
- Top Product
- Discover our top product TERF2IP Primary Antibody
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anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) antibody
TERF2IP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (Center) antibodyTERF2IP 适用: 人, 小鼠 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 1-280) antibodyTERF2IP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 1-399) antibodyTERF2IP 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 1664CT768-14-43 unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 142-191) antibodyTERF2IP 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴, 兔, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 1-280) antibodyTERF2IP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 1-280) antibodyTERF2IP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 215-264) antibodyTERF2IP 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 猴, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 212-235) antibodyTERF2IP 适用: 人 WB 宿主: 小鼠 Monoclonal 78B356-1 unconjugated
anti-Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP) (AA 212-235) antibodyTERF2IP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))
- 别名
- TERF2IP (TERF2IP 产品)
- 别名
- DRIP5 antibody, RAP1 antibody, Rap1 antibody, cRAP1 antibody, TERF2 interacting protein antibody, telomeric repeat binding factor 2, interacting protein antibody, TERF2IP antibody, Terf2ip antibody
- 背景
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Synonyms: RAP1, DRIP5, Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, PP8000
Background: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
- 基因ID
- 54386
- UniProt
- Q9NYB0
- 途径
- Cell Division Cycle, Telomere Maintenance
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