RORA 抗体 (AA 151-250)
Quick Overview for RORA 抗体 (AA 151-250) (ABIN4913739)
抗原
See all RORA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 151-250
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ROR alpha
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亚型
- IgG
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anti-RAR-Related Orphan Receptor A (RORA) antibody
KO Validated RORA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (Middle Region) antibodyRORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 山羊, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (Hinge Region) antibodyRORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴, Pig, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (N-Term) antibodyRORA 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (AA 193-222) antibodyRORA 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB16632 unconjugated
anti-RAR-Related Orphan Receptor A (RORA) antibodyRORA 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (AA 36-85) antibodyRORA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (Ligand Binding Domain) antibodyRORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (AA 1-468) antibodyRORA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor A (RORA) (AA 239-288) antibodyRORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴, 山羊, Pig, 斑马鱼, Bat, 绵羊, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- RORA (RAR-Related Orphan Receptor A (RORA))
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别名
- RORA
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背景
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Synonyms: ROR1, ROR2, ROR3, RZRA, NR1F1, RZR-ALPHA, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha, RORA
Background: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1.
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基因ID
- 6095
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UniProt
- P35398
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
抗原
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