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HINT1 抗体

This anti-HINT1 antibody is a 小鼠 单克隆 antibody detecting HINT1 in WB, IF, IF (cc), IHC (p) 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN4910644
发货至: 中国

Quick Overview for HINT1 抗体 (ABIN4910644)

抗原

See all HINT1 抗体
HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

适用

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人, 小鼠, 大鼠

宿主

  • 49
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小鼠

克隆类型

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单克隆

标记

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This HINT1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

克隆位点

5C3
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein G.

    免疫原

    This HINT1 antibody is generated from a mouse immunized with a recombinant protein of human HINT1.

    亚型

    IgG1
  • 应用备注

    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IF()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

    别名

    HINT1

    背景

    Synonyms: HINT, NMAN, PKCI-1, PRKCNH1, Histidine triad nucleotide-binding protein 1, Adenosine 5'-monophosphoramidase, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, HINT1, PKCI1

    Background: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

    基因ID

    3094

    UniProt

    P49773
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