Glucagon 抗体
Quick Overview for Glucagon 抗体 (ABIN4910082)
抗原
See all Glucagon (GCG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This Glucagon antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from human Glucagon.
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亚型
- IgG1
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anti-Glucagon (GCG) antibody
GCG 适用: 人 WB, IHC, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 21-180) antibodyGCG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 119-148), (C-Term) antibodyGCG 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB19525 unconjugated
anti-Glucagon (GCG) antibodyGCG 适用: 人 IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Glucagon (GCG) antibodyGCG 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 1-180) antibodyGCG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E2-E6 unconjugated
anti-Glucagon (GCG) (AA 53-81), (N-Term) antibodyGCG 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 53-81) antibodyGCG 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 23-180) antibodyGCG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucagon (GCG) (AA 25-54) antibodyGCG 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Glucagon (GCG)
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别名
- Glucagon
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背景
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Synonyms: GLP1, GLP2, GRPP, Glucagon, GCG
Background: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
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基因ID
- 2641
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UniProt
- P01275
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途径
- Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling
抗原
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