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EPH Receptor A5 抗体

This 小鼠 单克隆 anti-EPH Receptor A5 antibody (Clone 6C4) specifically detects EPH Receptor A5 in WB 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN4909184
发货至: 中国
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Quick Overview for EPH Receptor A5 抗体 (ABIN4909184)

抗原

See all EPH Receptor A5 (EPHA5) 抗体
EPH Receptor A5 (EPHA5)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This EPH Receptor A5 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

6C4
  • 交叉反应

    纯化方法

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

    免疫原

    Purified His-tagged EPHA5 protein(Fragment) was used to produced this monoclonal antibody.

    亚型

    IgG1
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    EPH Receptor A5 (EPHA5)

    别名

    EPHA5

    背景

    Synonyms: EK7, CEK7, EHK1, HEK7, EHK-1, TYRO4, Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EPH-like kinase 7, EPHA5, BSK

    Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

    基因ID

    2044

    UniProt

    P54756

    途径

    RTK signaling
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