MAP1LC3A 抗体
Quick Overview for MAP1LC3A 抗体 (ABIN4901877)
抗原
See all MAP1LC3A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- LC3A is a protein encoded by the MAP1LC3A gene which is approximately 14,3 kD. LC3A is localised to the cytoplasm, cytoskeleton and autophagosome. It is involved in pathways such as the autophagy pathway, pink/parkin mediated mitophagy, ferroptosis, cellular senescence and pathways affecting insulin-like growth factor-Akt signalling. MAP1A and MAP1B fall under the LC3A protein. They are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Mutations in the LC3A gene may result in Nasu-Hakola disease , lacrimal gland adenocarcinoma and leber congenital amaurosis. STJ97755 was developed from clone 5G10. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous levels of LC3A.
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特异性
- LC3A Mouse Monoclonal Antibody (5G10) detects endogenous levels of LC3A
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产品特性
- Mouse Monoclonal to LC3A.
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纯化方法
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
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免疫原
- synthetic peptide derived from LC3A
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亚型
- IgG1
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应用备注
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WB 1:1000-2000
IHC 1:100-200 -
说明
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Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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