HP-1α is a protein encoded by the CBX5 gene which is approximately 22,2 kDa. HP-1α is localised to the nucleus. It is involved in chromatin regulation and acetylation, E2F mediated regulation of DNA replication and aurora B signalling. It is a highly conserved non-histone protein that falls under the heterochromatin protein family. It has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins. It is also involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. HP-1α is expressed in the liver, nervous system, kidney, eye and intestine. Mutations in the CBX5 gene may result in Reynolds syndrome. STJ98895 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous HP-1α protein.
特异性
The antibody detects endogenous HP-1α protein.
产品特性
Mouse Monoclonal to HP-1α.
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.