ABCA4 抗体 (C-Term)
Quick Overview for ABCA4 抗体 (C-Term) (ABIN4889493)
抗原
See all ABCA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Reacts with primate ABCA4 protein: human, mouse, rat, dog, monkeys
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交叉反应 （详细）
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纯化方法
- Purified (protein A)
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免疫原
- Synthetic peptide derived from C terminal domain of human ABCA4 protein.
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anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2250-2263) antibody
Verified ABCA4 适用: 人, 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 1398-1727) antibodyABCA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) antibodyABCA4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2174-2273) antibodyABCA4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (C-Term) antibodyABCA4 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) antibodyABCA4 适用: Cow WB, IHC 宿主: 小鼠 Monoclonal 3F4 unconjugated
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应用备注
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Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only :
- WB : 1 to 5 μg/mL - IHC : 1/100 to 1/1000 -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Must be reconstituted in distilled water.
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浓度
- 1 mg/mL
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缓冲液
- Tris 0,1M, glycine 0,1M, sucrose 2 %
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储存条件
- 4 °C/-20 °C
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储存方法
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 24 months
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- ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))
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别名
- Retinal-Specific ATP-Binding Cassette Transporter
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背景
- Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) . In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
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UniProt
- P78363
抗原
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