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Cyclin D1 抗体 (AA 1-295)

CCND1 适用: 人, 小鼠, 大鼠, Non-Human Primate WB, FACS, IP, IHC (p), ICC, IHC (fro) 宿主: 小鼠 Monoclonal DCS-6 unconjugated
产品编号 ABIN4888511
发货至: 中国
  • 抗原 See all Cyclin D1 (CCND1) 抗体
    Cyclin D1 (CCND1)
    抗原表位
    • 21
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    AA 1-295
    适用
    • 235
    • 127
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    • 10
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    • 3
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    人, 小鼠, 大鼠, Non-Human Primate
    宿主
    • 204
    • 55
    • 1
    小鼠
    克隆类型
    • 193
    • 65
    单克隆
    标记
    • 116
    • 28
    • 21
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    This Cyclin D1 antibody is un-conjugated
    应用范围
    • 196
    • 89
    • 65
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    • 42
    • 30
    • 27
    • 27
    • 24
    • 21
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    • 12
    • 6
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    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    The mouse monoclonal antibody DCS-6 recognizes cyclin D1, an ubiquitously expressed 33 kDa intracellular protein that migrates as a 36 kDa band under reducing SDS-PAGE conditions.
    无交叉反应
    Cat, 绵羊
    交叉反应 (详细)
    Human, Non-Human Primates, Mouse, Rat
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    recombinant human cyclin D1 (amino acids 1-295)
    克隆位点
    DCS-6
    亚型
    IgG2a
    Top Product
    Discover our top product CCND1 Primary Antibody
  • 应用备注
    Immunohistochemistry: Recommended dilution: 5-10 μg/mL.
    Flow cytometry: Recommended dilution: 3-12 μg/mL. Intracellular staining.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • 抗原
    Cyclin D1 (CCND1)
    别名
    Cyclin D1 (CCND1 产品)
    别名
    BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody
    背景
    Cyclin D1,Cyclin D1 (PRAD1, Bcl-1) is a cytoplasmic and nuclear protein, which is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Whereas during G1 phase cyclin D1 accumulates in the nucleus, it translocates into the cytoplasm during S phase. Without growth factor-mediated stimulation, cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest.,CYC-D1, CCND1, Bcl-1, PRAD1, U21B31
    基因ID
    595
    UniProt
    P24385
    途径
    PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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